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Updated: Jun 12, 2025
Postproduction Processing of Electrospun Fibres for Tissue Engineering
Published on: August 9, 2012
In Vitro Culture of Human Dermal Fibroblasts on Novel Electrospun Polylactic Acid Fiber Scaffolds Loaded with
Eliza Miranda-Buendia1, Gertrudis H González-Gómez1, Alfredo Maciel-Cerda2
1Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico.
Abstract:
Polyepicatechin (PEC) in a hydrogel has previously shown promise in enhancing physiological properties and scaffold preparation. However, it remains unclear whether PEC-based fibers can be applied in skin tissue engineering (STE). This study aimed to synthesize and characterize electrospun PEC physical gels and polylactic acid (PLA) scaffolds (PLAloadedPECsub) for potential use as constructs with human dermal fibroblasts (HDFs). PEC was produced through enzymatic polymerization, as confirmed by Fourier transform infrared (FTIR) spectroscopy. Scanning electron microscopy (SEM) demonstrated the feasibility of producing PLAloadedPECsub by electrospinning. The metabolic activity and viability of HDFs cocultured with the scaffolds indicate that PLAloadedPECsub is promising for the use of STE.
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