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Antibacterial Properties of Grape Seed Extract-Enriched Cellulose Hydrogels for Potential Dental Application: In
Karla Lizette Tovar-Carrillo1, Lizett Trujillo-Morales1, Juan Carlos Cuevas-González1
1Instituto de Ciencias Biomédicas, Universidad Autónoma de Cd. Juárez, Av. Benjamín Franklin # 4960, Zona Pronaf, Ciudad Juárez 32315, Chihuahua, Mexico.
Gels (Basel, Switzerland)
|September 27, 2024
Summary
New hydrogels made from Dasylirion spp. and grape seed extract (GSE) show promise for dental applications. These materials exhibit strong antimicrobial properties against common oral bacteria, with 30% GSE inhibiting over 90% of growth.
Area of Science:
- Biomaterials Science
- Dental Materials
- Polymer Chemistry
Background:
- Development of novel biomaterials for dental applications is crucial for improving oral health treatments.
- Grape seed extract (GSE) possesses known antioxidant and antimicrobial properties, making it a candidate for bioactive material enrichment.
Purpose of the Study:
- To investigate the potential of hydrogels derived from Dasylirion spp. and enriched with grape seed extract (GSE) for dental applications.
- To evaluate the mechanical, physical, antimicrobial, biocompatibility, and cytotoxicity properties of cellulose-GSE hydrogels.
Main Methods:
- Cellulose-GSE hydrogels were fabricated with varying GSE concentrations (10–50 wt%).
- Mechanical properties (elongation, tensile strength), physical properties, antimicrobial activity against specific bacteria, biocompatibility, and in vitro cytotoxicity were assessed.
Main Results:
- GSE incorporation altered mechanical properties, decreasing elongation and tensile strength, yet hydrogels remained suitable for manipulation.
- All hydrogels demonstrated excellent biocompatibility and no cytotoxicity.
- Significant antibacterial activity was observed against Streptococcus mutans, Enterococcus Faecalis, Staphylococcus aureus, and Pseudomonas aureginosa, with 30 wt% GSE achieving >90% inhibition.
Conclusions:
- Cellulose-GSE hydrogels exhibit promising biocompatibility and potent antimicrobial effects, particularly at 30 wt% GSE concentration.
- These findings suggest the potential utility of GSE-enriched Dasylirion spp. hydrogels as novel materials in dental treatments.
