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On the Temporal Evolution of Key Hemofilter Parameters-In Vitro Study under Co-Current Flow.

Anastasios J Karabelas1, Alexandra Moschona1, Konstantinos Merenidis1

  • 1Chemical Process and Energy Resources Institute, Centre for Research and Technology-Hellas, Thermi, 57001 Thessaloniki, Greece.

Membranes
|September 27, 2024
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Summary

Co-current flow in hemofilters improves transmembrane pressure uniformity, leading to more accurate performance data. This method enhances understanding of hemofilter parameters during hemocatharsis.

Keywords:
albumin lossesco-current flowhemocatharsis parameterspermeabilitysieving coefficientultrafiltration coefficient

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Area of Science:

  • Biomedical Engineering
  • Fluid Mechanics

Background:

  • Hemofilter (HF) performance is critical for hemodialysis and hemocatharsis.
  • Accurate determination of parameters like effective permeability (KP) and ultrafiltration coefficient (KUF) is challenging.
  • Current counter-current flow may lead to non-uniform transmembrane pressure (TMP).

Purpose of the Study:

  • To demonstrate the benefits of co-current flow for unidirectional filtration and uniform TMP in hemofilters.
  • To investigate the temporal evolution of key hemofilter performance parameters under co-current flow.
  • To correlate protein mass flux with permeability under varying conditions.

Main Methods:

  • Experimental investigation using human plasma and BSA solutions in co-current flow mode.
  • Development of a fluid mechanical model to analyze flow dynamics.
  • Measurement of effective permeability (KP), ultrafiltration coefficient (KUF), sieving coefficient (SC), and protein mass flux (Mm).

Main Results:

  • Co-current flow achieved a fairly uniform local TMP, reducing axial variability.
  • Improved uniformity in local TMP led to more uniform protein membrane fouling.
  • Observed temporal variability and decline in KP due to membrane fouling, impacting other parameters.
  • Established a strong correlation between albumin/protein mass flux (Mm) and permeability (KP).

Conclusions:

  • Co-current flow facilitates accurate and representative data acquisition for hemofilter parameters.
  • Uniform TMP under co-current flow aids in interpreting and correlating HF performance data.
  • Results support further exploration of co-current flow for clinical hemocatharsis applications.