A Reference Interval for CT-Based Liver Volume in Dogs without Hepatic Disease

In both human and veterinary medicine, computed tomography (CT) volumetry provides a quantitative and accurate measure of liver volume. While CT volumetry is recognized as a useful method for assessing liver volume in dogs, a statistically significant reference interval for liver volume in dogs with no history of hepatic disease has not been reported. The purpose of the present study was to define a reference interval for liver volume with no history of hepatic disease using CT volumetry. Medical records from 2 June 2020 to 25 July 2022 were retrospectively reviewed, including 121 dogs that underwent abdominal CT scans and had no history of hepatic disease. Liver volumes were measured using CT volumetry and normalized by body weight. The median of normalized CT-based liver volume in 121 dogs was 22.2 cm³/kg. Based on these data, a weight-based reference interval lower limit of 11.1-15.5 (90% confidence interval [CI]) to an upper limit of 31.9-42.6 (90% CI) cm³/kg for CT-based liver volume was defined in dogs without hepatic disease. This study provides an accurate assessment of liver volume changes in dogs with various hepatic diseases.