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Cardiorenal syndrome: evolving concepts and pediatric knowledge gaps

Alexander J Kula1, Deirdre Bartlett2

  • 1Division of Pediatric Nephrology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 Chicago Ave, Chicago, Il, 60611, USA. alexkula@luriechildrens.org.

Pediatric Nephrology (Berlin, Germany)
|September 27, 2024
PubMed

Insights

Cardiorenal syndrome (CRS) involves heart and kidney dysfunction. Pediatric CRS research is crucial for improving outcomes in children and adolescents, requiring cross-system collaboration.

Area of Science:

  • Pediatric Cardiology
  • Nephrology
  • Cardiorenal Medicine

Background:

  • Cardiorenal syndrome (CRS) describes the interconnected dysfunction of the heart and kidneys.
  • The cardiorenal relationship is bidirectional, impacting both cardiac and renal health.
  • Existing research predominantly focuses on adult populations, leaving a gap in pediatric understanding.

Purpose of the Study:

  • To review key features of cardiorenal syndrome.
  • To highlight the need for pediatric-specific research in CRS.
  • To foster interdisciplinary collaboration for improved cardiorenal outcomes in young patients.

Main Methods:

  • Literature review of cardiorenal syndrome.
  • Analysis of existing research trends.
  • Identification of pediatric research opportunities.

Main Results:

  • CRS pathology is bidirectional, affecting both heart and kidney function.
  • High prevalence of kidney disease in cardiac patients and cardiovascular complications in kidney disease patients.
  • Limited research specifically addresses pediatric cardiorenal syndrome.

Conclusions:

  • Understanding CRS is vital for both cardiac and renal health.
  • Pediatric CRS requires dedicated research efforts.
  • Interdisciplinary collaboration is essential to advance pediatric cardiorenal outcomes.

Keywords:
Acute kidney injuryCardiorenal syndromeHeart failureWorsening in renal function

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