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Related Experiment Video

Updated: Jun 11, 2025

Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
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The Association Between Breast Cancer Predisposing Genetic Variants and Multifocal, Multicentric Breast Cancer.

Mahtab Vasigh1, Ahmed Mohamed1, Lisa Jacobs1

  • 1Department of Surgical Oncology, Johns Hopkins Medical Institute, Baltimore, MD, USA.

Annals of Surgical Oncology
|September 27, 2024
PubMed
Summary

Genetic variants in breast cancer genes do not increase the likelihood of multifocal or multicentric (MFMC) disease. This finding challenges previous assumptions and may impact treatment decisions for early-onset breast cancer patients with genetic predispositions.

Keywords:
BRCA1BRCA2Breast cancer-associated genetic variantsMultifocal multicentric breast cancer

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
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Area of Science:

  • Oncology
  • Genetics
  • Cancer Research

Background:

  • Breast-conserving surgery is often avoided in BRCA gene carriers with early-onset breast cancer due to concerns about multifocal or multicentric (MFMC) disease.
  • Genetic variants predisposing to breast cancer may influence tumor characteristics.

Purpose of the Study:

  • To compare the incidence of MFMC disease in breast cancer patients with and without pathogenic genetic variants.
  • To determine if genetic variants are predictors of MFMC disease in early-onset breast cancer.

Main Methods:

  • Retrospective study of 282 newly diagnosed breast cancer patients undergoing genetic testing (2010-2021).
  • Patients were categorized into genetic variant positive or negative groups, excluding those with neoadjuvant chemotherapy or stage IV cancer.
  • Pathologic features, including MFMC disease (defined as >1 malignant focus >5 mm apart), were compared between groups.

Main Results:

  • 24% of patients tested positive for a breast cancer-associated genetic variant.
  • Variant carriers were younger, more likely to have invasive ductal carcinoma, mastectomy, and grade 3 cancer.
  • No significant difference in MFMC disease rates was observed between variant carriers (28%) and non-carriers (22%).

Conclusions:

  • Breast cancers in genetic variant carriers are not more likely to be multifocal or multicentric (MFMC) than sporadic cancers.
  • Positive genetic variant status was not a predictor of MFMC disease in this cohort.