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Updated: Jun 11, 2025
05:17
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
115
Amyloid related imaging abnormalities in the emergency setting.
Jan Czerminski1, Supriya Khatri2, Balaji Rao3
1Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Emergency Radiology
|September 27, 2024
Summary
Monoclonal antibody therapies for Alzheimer's disease (AD) target amyloid plaques but carry risks like amyloid-related imaging abnormalities (ARIA). This case highlights severe ARIA, emphasizing the need for radiologist expertise in managing these novel AD treatments.
Area of Science:
- Neurology
- Radiology
- Pharmacology
Background:
- The advent of monoclonal antibody (MAB) therapies marks a shift in Alzheimer's disease (AD) treatment, moving beyond symptom management to directly target amyloid-beta plaque reduction.
- FDA approval of MABs for AD offers new therapeutic avenues but introduces potential risks, notably amyloid-related imaging abnormalities (ARIA).
Observation:
- A 64-year-old woman receiving donanemab treatment for AD experienced severe ARIA.
- The observed ARIA manifested as extensive vasogenic edema and multiple microhemorrhages on imaging.
Findings:
- The case illustrates a severe presentation of ARIA-E (edema and effusion) and ARIA-H (hemorrhage) in a patient undergoing MAB therapy.
- Diagnostic imaging was crucial in identifying and characterizing the extent of these abnormalities.
Implications:
- Increased utilization of MABs in AD necessitates enhanced vigilance and diagnostic skill among emergency radiologists.
- Prompt identification of ARIA is critical for timely intervention and optimal patient management during novel Alzheimer's disease therapies.
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