Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

394
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
394
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.3K
Epistasis Analysis01:09

Epistasis Analysis

4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K
Human Genetics01:28

Human Genetics

540
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
540
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.6K
Genetic Lingo01:11

Genetic Lingo

101.8K
Overview
101.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

H<sub>2</sub>O<sub>2</sub>-independent oxygen activation via proton-coupled electron transfer for selective hydroxyl radical generation.

Water research·2026
Same author

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid-Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

pH Gradient at the Nanoscale Zerovalent Iron-Water Interface: Spatial Distribution, Formation Mechanism, and Impacts.

Environmental science & technology·2026
Same author

N-<i>p</i>-<i>trans</i>-Coumaroyltyramine Improves Myocardial Ischemia-Reperfusion Injury: From Cellular Protection to Animal Model Validation and the Discovery of the Target Tcap.

International journal of molecular sciences·2026
Same author

Solar-Powered Asymmetric C-C Coupling toward Efficient CO<sub>2</sub>-to-C<sub>2+</sub> Hydrocarbon Conversion at Ultralow Bias.

Journal of the American Chemical Society·2026
Same author

Bypassing Hydrogenation Pathway for Sustainable Nitrate Water Remediation via Direct N─N Coupling.

Angewandte Chemie (International ed. in English)·2026
Same journal

Noninvasive Diagnosis Revealed a Strong Therapeutic Response and Skin Barrier Changes in Hemoporfin-Mediated Photodynamic Therapy for Port-Wine Stains.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2026
Same journal

In Vivo Microscopic Features of Acne vulgaris Revealed via LC-OCT.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2026
Same journal

Intravital Monitoring of Psoriasis Treatment Response and Drug Delivery Using Multiphoton Fluorescence Lifetime Imaging.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2026
Same journal

Retinol-Loaded Mannosylerythritol Lipid Nanoliposome for Enhanced Human Skin Penetration.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2026
Same journal

Artificial Intelligence in Dermatology: New Regulatory Aspects After the European AI Act.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2026
Same journal

Reduction of Ultraviolet- and Heat-Induced Aging Using Betulin-Loaded Arginine-Caprylate Self-Assembly: Randomized Double-Blind Clinical Trials.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

8.9K

Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction Causality Analysis Study.

Yue Zhao1, Furong Guo2, Mengyue Guo2

  • 1Department of Dermatology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|September 27, 2024
PubMed
Summary
This summary is machine-generated.

This study found a causal link between hypothyroidism, Hashimoto's thyroiditis, and subacute thyroiditis with alopecia areata (AA). These findings suggest thyroid dysfunction may contribute to AA development, aiding future prevention and treatment strategies.

Keywords:
Mendelian randomizationalopecia areatacausal relationshipgenetic evidencethyroid dysfunction

More Related Videos

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K

Related Experiment Videos

Last Updated: Jun 11, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

8.9K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.6K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K

Area of Science:

  • Genetics
  • Immunology
  • Endocrinology

Background:

  • Observational studies suggest a link between alopecia areata (AA) and thyroid dysfunction (TD).
  • The causal relationship between AA and TD remains unclear.
  • Understanding this link is crucial for AA pathogenesis and developing novel treatments.

Purpose of the Study:

  • To investigate the causal relationship between specific thyroid dysfunctions and alopecia areata.
  • To elucidate the underlying pathogenesis of AA.
  • To inform the prevention and treatment of AA and its complications.

Main Methods:

  • Two-sample Mendelian randomization (MR) study using public GWAS data.
  • Exposure factors included hypothyroidism, Hashimoto's thyroiditis, hyperthyroidism, subacute thyroiditis, and Graves' disease.
  • Analyzed association using IVW, MR-Egger, and weighted median methods, with heterogeneity and pleiotropy tests.

Main Results:

  • Statistically significant genetic predictions of AA were found with hypothyroidism, Hashimoto's thyroiditis, and subacute thyroiditis.
  • No evidence of pleiotropy was detected, supporting the study's validity.
  • Leave-one-out analysis confirmed the stability and robustness of the observed associations.

Conclusions:

  • This study provides evidence for a causal genetic link between hypothyroidism, Hashimoto's thyroiditis, subacute thyroiditis, and AA.
  • The MR method minimized confounding factors and reverse causation, yielding unbiased results.
  • Further research into the biological mechanisms connecting TD and AA onset is warranted.