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Related Experiment Video

Updated: Jun 11, 2025

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[Licorice consumption can be life-threatening].

Olafur Orri Sturluson1, Birgir Johannsson1, Helga Agusta Sigurjonsdottir2

  • 1Department of Medicine, Landspitali University Hospital.

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PubMed
Summary
This summary is machine-generated.

Excessive liquorice consumption can cause severe hypokalemia and hypertension. This case highlights liquorice-induced hypertension and apparent mineralocorticoid excess, emphasizing clinical awareness of this risk.

Keywords:
aldosteronegervi aldosteron heilkennilicorice poisoningliquoriceliquorice induced hypertensionpseudo-hyperaldosteronism

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Area of Science:

  • Endocrinology
  • Nephrology
  • Toxicology

Background:

  • Liquorice contains glycyrrhizic acid, a compound that mimics mineralocorticoids.
  • Excessive consumption can lead to electrolyte imbalances and hypertension.

Observation:

  • A 71-year-old male presented with hypokalemia (2.1 mmol/L), muscle weakness, and new-onset hypertension.
  • He reported consuming over 250g of liquorice daily.
  • Investigations revealed atrial fibrillation, increased urinary potassium excretion, and suppressed renin and aldosterone levels.

Findings:

  • The patient was diagnosed with liquorice-induced hypertension and apparent mineralocorticoid excess (pseudohyperaldosteronism).
  • Influenza A infection was also noted but considered secondary to the primary endocrine disturbance.

Implications:

  • Clinicians must consider excessive liquorice intake in patients presenting with hypokalemia and hypertension.
  • Awareness of liquorice toxicity is crucial for accurate diagnosis and management of mineralocorticoid excess syndromes.