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Updated: Jun 11, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Using residue interaction networks to understand protein function and evolution and to engineer new proteins.

Dariia Yehorova1, Bruno Di Geronimo1, Michael Robinson2

  • 1School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA-30332, USA.

Current Opinion in Structural Biology
|September 27, 2024
PubMed
Summary

Residue interaction networks (RINs) map protein interactions to understand structure and function. Comparative RIN analysis, or metaRINs, aids in dissecting protein evolution and engineering new proteins.

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