Advanced mathematical modeling for preciseestimation of CT energy spectrum using a calibration phantom

This research aims to develop an advanced mathematical model using a CT calibration phantom to accurately estimate the CT energy spectrum in clinical settings, enhancing imaging quality and patient dose management.

Data were collected from a CT scanner using a CT calibration phantom at various energy levels (80, 100, 120, and 135 kVp). The data was optimized to refine the energy spectrum model, followed by cross-validation with Monte Carlo simulations.

The developed model demonstrated high precision in estimating the CT energy spectrum at all tested energy levels, with R-squared values above 0.9738 and an R-squared value of 0.9829 at 100 kVp. The model also showed low Normalized Root Mean Square Deviation (NRMSD) ranging from 0.6698 % to 1.8745 %. The Mean Energy Difference (ΔE) between the estimated and simulated spectrum consistently remained under 0.01 keV. These results were comparable to recent studies, which reported higher NRMSD and ΔE.

This study presents a significantly improved model for estimating the CT energy spectrum, offering greater accuracy than existing models. Its strengths include high precision and the use of standard equipment and algorithmic values. While the current use of 13 plugs is adequate, incorporating plugs with varied densities could enhance accuracy. This model has potential for improving imaging quality and optimizing patient dosing in clinical applications. Future trends may include extending energy spectrum estimation to megavoltage domains and integrating technologies like EPID and MVCT for better dose distribution prediction in high-energy photon beam therapy.