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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

394
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

680
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Stress responses, M2 macrophages, and a distinct microbial signature in fatal intestinal acute graft-versus-host disease.

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Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion.

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Outcomes and Predictors of Response in Steroid-Refractory Acute Graft-versus-Host Disease.

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Validation of Minnesota acute graft-<i>versus</i>-host disease Risk Score.

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Related Experiment Video

Updated: Jun 11, 2025

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

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Challenges and solutions for cellular therapy development in autoimmune diseases

Elizabeth R Volkmann1, John Varga2, Bruce R Blazar3

  • 1Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

The Lancet. Rheumatology
|September 27, 2024
PubMed
Summary

No abstract available in PubMed .

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