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Updated: Jun 11, 2025

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Nuclear Receptor Interdomain Communication is Mediated by the Hinge with Ligand Specificity

Saurov Hazarika1, Tracy Yu2, Arumay Biswas1

  • 1Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA.

Journal of Molecular Biology
|September 27, 2024
PubMed
Summary

Ligand binding to nuclear receptors like farnesoid X receptor (FXR) causes domain rearrangement. Computational modeling and experiments reveal the hinge region is crucial for this interdomain communication.

Keywords:
Farnesoid X receptorHomology modelingInterdomain communicationMolecular dynamics simulationsMultidomain proteinsNuclear receptors

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