Related Experiment Video

Updated: Jun 11, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

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Role of the RNA binding protein IGF2BP1 in cancer multidrug resistance

Aldana Magalí Gola1, María Bucci-Muñoz1, Juan Pablo Rigalli2

  • 1Instituto de Fisiología Experimental (CONICET) - Facultad de Ciencias Bioquímicas y Farmacéuticas (UNR), Rosario, Argentina.

Biochemical Pharmacology
|September 27, 2024
PubMed

Insights

Insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) is crucial for cancer development and multidrug resistance (MDR). This review details IGF2BP1

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Insulin-like growth factor-2 mRNA-binding protein 1 (IGF2BP1) is highly expressed in fetal tissues and numerous cancers, but minimally in normal adult tissues.
  • IGF2BP1 plays a critical role in transporting specific mRNAs from the nucleus to the cytoplasm, influencing embryogenesis, carcinogenesis, and multidrug resistance (MDR).

Purpose of the Study:

  • To review mechanisms of MDR in cancer.
  • To elucidate the significance of IGF2BP1 in the context of cancer MDR.
  • To detail IGF2BP1's tissue distribution, expression, molecular targets, and inhibitors in tumorigenesis.

Main Methods:

  • Literature review focusing on IGF2BP1's role in cancer.
  • Analysis of IGF2BP1's interplay with MDR mechanisms, particularly chemoresistance mediated by ABC transporters.

Main Results:

  • IGF2BP1 is implicated in essential cellular processes including embryogenesis and carcinogenesis.
  • IGF2BP1 affects mRNA stability, translation, and localization, contributing to MDR.
  • The review highlights the specific connection between IGF2BP1 and ABC transporter-mediated chemoresistance.

Conclusions:

  • IGF2BP1 is a key factor in cancer development and the emergence of multidrug resistance.
  • Understanding IGF2BP1's function is crucial for developing strategies to overcome chemoresistance in cancer patients.
Keywords:
ABC transportersCancerChemotherapyIGF2BP1Multidrug resistance

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