Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurological sequelae after intoxication with sodium valproate.

D Bigler

    Acta Neurologica Scandinavica
    |September 1, 1985
    PubMed
    Summary

    Valproic acid poisoning can cause severe brain, heart, and liver damage, leading to prolonged coma and lasting neurological issues like vision reduction. This case highlights the critical toxicity of valproate.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impact of off-pump coronary artery surgery on myocardial performance and beta-adrenoceptor function.

    Journal of cardiothoracic and vascular anesthesia·2001
    Same author

    Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of beta1 integrin-associated proteins CD9, CD81, and CD98.

    Molecular biology of the cell·2001
    Same author

    Sequence-specific interaction between the disintegrin domain of mouse ADAM 2 (fertilin beta) and murine eggs. Role of the alpha(6) integrin subunit.

    The Journal of biological chemistry·2000
    Same author

    Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization.

    Proceedings of the National Academy of Sciences of the United States of America·1999
    Same author

    Monitoring of beta-receptor sensitivity in cardiac surgery.

    Journal of cardiothoracic and vascular anesthesia·1999
    Same author

    A model for sperm-egg binding and fusion based on ADAMs and integrins.

    Trends in cell biology·1997

    Area of Science:

    • Neurology
    • Toxicology
    • Pharmacology

    Background:

    • Valproic acid is a widely used antiepileptic and mood-stabilizing drug.
    • While generally safe, valproate overdose can lead to significant toxicity.

    Observation:

    • A severe case of valproic acid poisoning is presented.
    • The patient experienced prolonged coma (13 days) and multi-organ involvement, including the brain, heart, and liver.
    • Neurological sequelae, such as persistent visual impairment, were noted even after two months.

    Findings:

    • Valproic acid overdose can result in profound central nervous system depression, manifesting as deep coma.
    • Significant hepatic and cardiac toxicity can accompany valproate poisoning.
    • Neurological deficits, including visual disturbances, may persist long after the acute poisoning phase.

    Implications:

    • This case underscores the importance of careful dosing and monitoring in patients treated with valproic acid.
    • Awareness of potential severe toxic effects is crucial for clinicians managing valproate overdose.
    • Further research into the mechanisms of valproate-induced neurotoxicity and organ damage is warranted.

    Related Experiment Videos