Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.0K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

7.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.3K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

1.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
1.3K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

2.4K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Whole-Gut Spatial Genomic Analysis Reveals Molecular Regionalization of the Differentiating Zebrafish Enteric Nervous System.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025
Same author

BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development.

Developmental dynamics : an official publication of the American Association of Anatomists·2024
Same author

Expansion of a neural crest gene signature following ectopic MYCN expression in sympathoadrenal lineage cells in vivo.

PloS one·2024
Same author

A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system.

PloS one·2024
Same author

A targeted CRISPR-Cas9 mediated F0 screen identifies genes involved in establishment of the enteric nervous system.

bioRxiv : the preprint server for biology·2024
Same author

Genetic regulation of enteric nervous system development in zebrafish.

Biochemical Society transactions·2024
Same journal

Direct Reciprocal Repression between Goosecoid and Ventx1.1 Modulates Dorsoventral Patterning in Xenopus.

Differentiation; research in biological diversity·2026
Same journal

Validated CRISPR/Cas9 guide RNAs targeting neurodevelopmental genes in the tunicate Ciona robusta.

Differentiation; research in biological diversity·2026
Same journal

Corrigendum to "Histone H2A deubiquitinase BAP1 is required for human neuronal progenitor cell formation" [Differentiation 149 (2026) 100957].

Differentiation; research in biological diversity·2026
Same journal

Human heel fat pad development before birth.

Differentiation; research in biological diversity·2026
Same journal

Bridging cells: Potential crosstalk between the peripheral and central olfactory sensory system.

Differentiation; research in biological diversity·2026
Same journal

Osteoclast-derived DEL1 promotes pathological bone formation in ankylosing spondylitis by regulating RUNX2 expression in osteoblasts.

Differentiation; research in biological diversity·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2025

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
07:21

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

7.4K

Fibroblast Growth Factor (FGF) 13.

Lucia J Rivas1, Rosa A Uribe1

  • 1Department of Biosciences, Rice University, Houston, TX, United States; Biochemistry and Cell Biology Graduate Program, Rice University, Houston, TX, United States.

Differentiation; Research in Biological Diversity
|September 27, 2024
PubMed
Summary
This summary is machine-generated.

Fibroblast Growth Factor (FGF) 13, a neuronal protein, interacts with key cellular components and is implicated in neurological disorders. Mutations in FGF13 are linked to human X-linked neurological diseases.

Keywords:
FGF homologous factorFGF13FHF2Fibroblast growth factor

More Related Videos

Murine Dermal Fibroblast Isolation by FACS
06:04

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

21.0K
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

2.4K

Related Experiment Videos

Last Updated: Jun 11, 2025

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay
07:21

Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay

Published on: December 26, 2019

7.4K
Murine Dermal Fibroblast Isolation by FACS
06:04

Murine Dermal Fibroblast Isolation by FACS

Published on: January 7, 2016

21.0K
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
08:34

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion

Published on: February 24, 2021

2.4K

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • Fibroblast Growth Factor (FGF) 13, also known as FGF homologous factor 2 (FHF2), belongs to the FGF11 subfamily.
  • Unlike classical FGFs, FGF13 does not bind FGF receptors (FGFRs) despite sequence similarities.
  • FGF13 is a non-secreted protein found in neurons and heart tissue, present from embryonic stages to adulthood.

Purpose of the Study:

  • To review current knowledge on FGF13, including its expression, mutant analyses, and structure.
  • To highlight FGF13's functional interactions and subcellular localization.
  • To discuss the role of FGF13 in neurological pathologies and human diseases.

Main Methods:

  • Review of existing literature on FGF13 expression patterns.
  • Analysis of data from Fgf13 mutant mouse models.
  • Sequence mapping to identify FGF13 as a candidate gene for human diseases.

Main Results:

  • FGF13 is expressed in developing and mature neurons of the central and peripheral nervous systems, and the heart.
  • FGF13 localizes to both the cytoplasm and nucleus, interacting with proteins like IB2, microtubules, and sodium channels.
  • Fgf13 mutant mice exhibit neurological pathologies, and FGF13 mutations are linked to human X-linked neurological diseases.

Conclusions:

  • FGF13 plays a significant role in neuronal function and development.
  • Its interactions with various cellular targets underscore its adaptability and importance.
  • FGF13 is a critical gene implicated in the etiology of several X-linked neurological disorders.