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Posttraumatic syrinx formation: experimental study.

W A Cohen, W Young, V DeCrescito

    AJNR. American Journal of Neuroradiology
    |September 1, 1985
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    Computed tomography (CT) with intrathecal contrast revealed spinal cord cavitation in cats after injury. Metrizamide contrast caused seizures, unlike iopamidol, highlighting safety differences in spinal cord imaging.

    Area of Science:

    • Veterinary Radiology
    • Neurology
    • Experimental Pathology

    Background:

    • Posttraumatic spinal cord injury can lead to cavitation, a significant pathological change.
    • Accurate imaging of spinal cord injury requires effective contrast agents and techniques.

    Purpose of the Study:

    • To evaluate spinal cord cavitation using computed tomography (CT) with intrathecal contrast in an animal model.
    • To assess the safety and efficacy of different intrathecal contrast agents (metrizamide and iopamidol) in cats with spinal cord injury.

    Main Methods:

    • Experimental spinal cord contusion was induced in four cats using a 400 g-cm model.
    • Computed tomography (CT) scans with intrathecal contrast were performed before and at multiple time points after injury.
    • Histopathological examination was conducted to correlate with CT findings.

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    Main Results:

    • Two cats showed CT and pathological evidence of spinal cord cavitation at the injury site.
    • One cat exhibited contrast uptake indicative of malacic change without cavitation.
    • Metrizamide administration led to generalized myoclonic seizures, whereas iopamidol did not.

    Conclusions:

    • CT with intrathecal contrast is effective in visualizing posttraumatic spinal cord cavitation and malacia.
    • Iopamidol is a safer intrathecal contrast agent than metrizamide in cats with spinal cord injury due to the absence of adverse neurological events.