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Related Experiment Videos

Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis.

G Di Minno, J Martinez, M L McKean

    The American Journal of Medicine
    |November 1, 1985
    PubMed
    Summary

    Platelet dysfunction in uremia causes bleeding tendencies due to impaired aggregation and secretion, linked to poor arachidonic acid release. Hemodialysis partially improves these defects, but storage pool issues persist.

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    Area of Science:

    • Hematology
    • Nephrology
    • Platelet Physiology

    Background:

    • Uremia is associated with a bleeding tendency.
    • Platelet dysfunction is a suspected cause of this bleeding tendency.

    Purpose of the Study:

    • To investigate in vitro platelet functions in patients with uremia undergoing hemodialysis.
    • To elucidate the nature of platelet dysfunction in uremia.

    Main Methods:

    • Studied platelet aggregation, thromboxane B2 formation, and adenosine diphosphate (ADP) and adenosine triphosphate (ATP) secretion in patients undergoing hemodialysis.
    • Compared platelet function in uremic patients with and without prior hemodialysis.

    Main Results:

    • Platelets from uremic patients showed impaired aggregation in response to collagen, ADP, and epinephrine, but normal response to arachidonic acid and U-46619.

    Related Experiment Videos

  • Thromboxane B2 formation was decreased in response to thrombin, collagen, and combined agonists, but normal with arachidonic acid.
  • A partial reduction in platelet ADP content and impaired ATP secretion indicated a storage pool defect.
  • Hemodialysis partially corrected aggregation and thromboxane B2 formation, but not ADP content.

    • Conclusions:

    • Platelet dysfunction in uremia is multifaceted, involving aggregation and secretion defects related to impaired arachidonic acid release.
    • A storage pool defect in platelets also contributes to bleeding tendencies in uremia.
    • Hemodialysis offers partial improvement for some platelet defects, but not the storage pool defect.