Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cadherins in Tissue Organization

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...

Cell-matrix's Response to Mechanical Forces

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...

Cell Migration

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

Intracellular Signaling Affects Focal Adhesions

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

Tension Response at Adherens Junctions

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...

Overview of Cell-Matrix Interactions

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.

Nature communications·2026

Same author

Structural Dynamics of the Afamin/Wnt3a Complex Mediated by the Afamin Hydrophobic Pocket.

Nano letters·2026

Same author

Synthesis of Multisubstituted Diazatricyclic Molecules Via Intramolecular Cycloaddition of Cyclic Azomethine Ylides.

Organic letters·2026

Same author

Read-across prediction of nongenotoxic thyroid carcinogenicity of pesticides in rats using mechanism-based in vitro assay data.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026

Same author

The Minimal Important Change of the Fugl-Meyer Assessment-Lower Extremity Motor Scale in Patients With Acute Stroke.

Archives of physical medicine and rehabilitation·2026

Same author

Characterization of the toxicological findings from 90-day and 2-year repeated-dose toxicity studies of pesticides in rats.

The Journal of toxicological sciences·2025

Same journal

Arf1 is involved in Neisseria meningitidis-induced cortical branched F-actin network reorganization.

EMBO reports·2026

Same journal

Spontaneous membrane protrusion and cell morphogenesis via self-propelled actin filaments.

EMBO reports·2026

Same journal

Science's temporary workforce : The use of temporary contracts in research has reached a crisis point in Italy but the problem is prevalent across Europe.

EMBO reports·2026

Same journal

Validation of the mRNA epitranscriptome: SCARPET reveals that mapped m<sup>1</sup>A sites are inosine.

EMBO reports·2026

Same journal

The mechanisms of DEPDC7-mediated actin cap establishment and meiosis progression in oocytes.

EMBO reports·2026

Same journal

E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression.

EMBO reports·2026

See all related articles

Search research articles

Home
Robust Tissue Pattern Formation By Coupling Morphogen Signal And Cell Adhesion.

Home
Robust Tissue Pattern Formation By Coupling Morphogen Signal And Cell Adhesion.

Related Experiment Video

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

Robust tissue pattern formation by coupling morphogen signal and cell adhesion.

Kosuke Mizuno^1,2,3, Tsuyoshi Hirashima^4,5, Satoshi Toda^6,7

¹WPI Nano Life Science Institute (NanoLSI), Kanazawa University, Kanazawa, Ishikawa, Japan.

|September 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Cells use morphogen gradients and adhesion to form precise tissue patterns. This study reveals how cadherin-based adhesion refines patterns, creating sharp boundaries and uniform domains for tissue engineering.

Keywords:

Cadherin Cell Adhesion Morphogen Pattern Formation Synthetic Biology

More Related Videos

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Published on: March 8, 2017

Related Experiment Videos

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Published on: March 8, 2017

Area of Science:

Developmental Biology
Tissue Engineering
Cellular Biophysics

Background:

Morphogens guide tissue patterning via concentration gradients.
Mechanisms linking morphogen diffusion to precise spatial patterns amidst biological noise are not fully understood.

Purpose of the Study:

To investigate how cells respond to diffusing morphogens to generate tissue patterns.
To explore the role of cell adhesion in morphogen-driven tissue patterning.

Main Methods:

Development of SYMPLE3D, a novel 3D culture platform.
Engineering gene expression responsive to artificial morphogens.
Analyzing the interplay between morphogen signaling and cadherin-based adhesion.

Main Results:

Coupling morphogen signals with cadherin-based adhesion converts gradients into distinct tissue domains.
Morphogen-induced cadherins aggregate activated cells, eliminating ectopic cells.
Switch-like induction of cadherin-mediated compaction and cell mixing creates uniformly activated domains with sharp boundaries.

Conclusions:

Cooperation between morphogen gradients and cell adhesion ensures robust tissue patterning.
This study introduces a novel method for engineering new tissue domains in organoids.