Gender-specific association between circulating serum Klotho and metabolic components in adults

Area of Science:

• Endocrinology and Metabolism
• Gerontology
• Cardiovascular Health

Background:

• Klotho is crucial for aging and cardiovascular health.
• Metabolic syndrome (MetS) components increase risks for cardiovascular disease and diabetes.
• Understanding gender-specific Klotho differences and MetS links is important.

Purpose of the Study:

• To investigate gender-specific differences in serum Klotho levels.
• To examine the association between Klotho and components of metabolic syndrome.
• To identify gender-specific factors related to Klotho and MetS.

Main Methods:

• Analysis of the 2015-2016 National Health and Nutrition Examination Survey database.
• Metabolic syndrome defined using 2005 AHA/NHLBI criteria.
• Examination of gender-specific differences in serum Klotho and its association with MetS components.

Main Results:

• Lower Klotho associated with older age, male sex, smoking, high triglycerides, kidney issues, inflammation, and low sex hormones.
• Klotho-MetS correlation stronger in women (waist circumference, triglycerides).
• Gender differences found in factors associated with Klotho, independent of age and renal function.

Conclusions:

• Klotho levels exhibit gender disparities, independent of age, renal function, and sex hormones.
• Triglycerides are a major MetS component independently linked to Klotho, especially in women.
• High-density lipoprotein cholesterol (HDL) is a male-specific MetS component independently associated with Klotho.