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Published on: September 11, 2015
Characterization and biocompatibility of a bilayer PEEK-based scaffold for guiding bone regeneration
Shaoping Li1, Cancan Jia1, Haitong Han1
1Key Laboratory of Stomatology in Hebei Province, Hospital of Stomatology Hebei Medical University, Shijiazhuang, China.
Background:
Polyetheretherketone (PEEK) is well known for its excellent physical-chemical properties and biosafety. The study aimed to open up a new method for clinical application of PEEK to reconstruct large-scale bone defects.
Methods:
A bilayer scaffold for bone regeneration was prepared by combining a sulfonated PEEK barrier framework (SPEEK) with a hydrogel layer loaded with aspirin (ASA) and nano-hydroxyapatite (nHAP) by the wet-bonding of Polydopamine (PDA).
Results:
The hydrogel was successfully adhered to the surface of SPEEK, resulting in significant changes including the introduction of bioactive groups, improved hydrophilicity, and altered surface morphology. Subsequent tests confirmed that the bilayer scaffold exhibited enhanced compression resistance and mechanical compatibility with bone compared to a single hydrogel scaffold. Additionally, the bilayer scaffold showed stable and reliable bonding properties, as well as excellent biosafety verified by cell proliferation and viability experiments using mouse embryo osteoblast precursor (MC3T3-E1) cells.
Conclusion:
The bilayer bone regeneration scaffold prepared in this study showed promising potential in clinical application for bone regeneration.
