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LINC01089 in cancer: multifunctional roles and therapeutic implications
Qiang Yi1, Gangfeng Zhu1, Xinting Ouyang1
1The First Clinical Medical College, Gannan Medical University, Ganzhou, 341000, Jiangxi, China.
Abstract:
LINC01089 is a prime example of a long non-coding RNA that plays a pivotal role in the progression of human cancers. The gene encoding this lncRNA is located on 12q24.31. LINC01089 has been demonstrated to exert tumor-suppressive effects in various cancers, including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, cervical cancer, papillary thyroid carcinoma, breast cancer, and osteosarcoma. However, its role in hepatocellular carcinoma shows significant discrepancies across different studies. In this review, we systematically explore the functions of LINC01089 in human cancers through bioinformatics analysis, clinical studies, animal models, and fundamental experimental research. Furthermore, we delve into the biological mechanisms and functions of LINC01089, and discuss its potential as a future biomarker and therapeutic target in detail.
Insights
Long non-coding RNA LINC01089 shows tumor-suppressive roles in many cancers. This review explores its functions, mechanisms, and potential as a biomarker and therapeutic target in human cancers.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are critical regulators in biological processes.
- LINC01089, located at 12q24.31, is implicated in various human cancers.
- Its function is predominantly tumor-suppressive, but its role in hepatocellular carcinoma requires clarification.
Purpose of the Study:
- To systematically review the multifaceted roles of LINC01089 in human cancer progression.
- To elucidate the biological mechanisms and functions governed by LINC01089.
- To assess the potential of LINC01089 as a diagnostic biomarker and therapeutic target.
Main Methods:
- Bioinformatics analysis.
- Review of clinical studies.
- Examination of animal models.
- Analysis of fundamental experimental research.
Main Results:
- LINC01089 exhibits tumor-suppressive activity in colorectal, gastric, lung, ovarian, cervical, breast cancers, and osteosarcoma.
- Conflicting evidence exists regarding LINC01089's role in hepatocellular carcinoma.
- Detailed exploration of LINC01089's molecular functions and pathways.
Conclusions:
- LINC01089 is a significant lncRNA with demonstrated tumor-suppressive functions across multiple cancer types.
- Further research is needed to resolve discrepancies in its role in hepatocellular carcinoma.
- LINC01089 holds promise as a potential biomarker and therapeutic strategy for cancer treatment.
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