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Nonlinear association between atherogenic index of plasma and chronic kidney disease: a nationwide cross-sectional

Bo Wang1, Chunqi Jiang2, Yinuo Qu2

  • 1Central Hospital of Jinan City, No. 105, Jiefang Road, Jinan City, Shandong Province, China.

Lipids in Health and Disease
|September 28, 2024
PubMed

Insights

The atherogenic index of plasma (AIP) shows a complex, non-linear link with chronic kidney disease (CKD). This relationship varies, with AIP inversely related to CKD below a certain threshold and positively related above it.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Disorders

Background:

  • Metabolic disorders and chronic kidney disease (CKD) have established links.
  • The association between CKD and atherogenic index of plasma (AIP) is less understood.
  • This study investigates the relationship between AIP and CKD.

Purpose of the Study:

  • To explore the correlation between AIP and CKD.
  • To identify potential non-linear associations.
  • To determine the inflection point of this relationship.

Main Methods:

  • Weighted multivariate logistic regression was used.
  • Smooth curve fitting analyzed curvilinear relationships.
  • Recursive partitioning and two-stage linear regression identified inflection points.
  • Stratified analyses examined subgroup heterogeneity.

Main Results:

  • Initial regression showed no significant linear association between AIP and CKD.
  • Sensitivity and smooth curve analyses revealed a non-linear relationship.
  • An inflection point was identified at AIP = -0.55.
  • Below -0.55, AIP was inversely correlated with CKD; above it, AIP was positively correlated.
  • Non-linear associations were noted in females and individuals aged 50+.

Conclusions:

  • A significant curvilinear relationship exists between CKD and AIP.
  • The nature of the association depends on the AIP threshold.
Abstract

Keywords:
Atherogenic index of plasmaChronic kidney diseaseCross-sectional studyCurvilinearNHANES

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