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Updated: Jun 11, 2025

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Inhibition of Oxidative Stress and Related Signaling Pathways in Neuroprotection

Maja Jazvinšćak Jembrek1,2

  • 1Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, Croatia.

Antioxidants (Basel, Switzerland)
|September 28, 2024
PubMed

Insights

Oxidative stress contributes to neurodegeneration by increasing reactive oxygen species (ROS) and disrupting redox balance, leading to synaptic loss and neuronal death in brain diseases.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Oxidative stress, marked by elevated reactive oxygen species (ROS) and impaired redox homeostasis, is a critical factor in neurodegenerative diseases.
  • This imbalance contributes significantly to synaptic dysfunction and neuronal apoptosis.

Discussion:

  • The study investigates the intricate relationship between oxidative stress markers and neurodegeneration.
  • Understanding these mechanisms is crucial for developing targeted therapeutic strategies.

Key Insights:

  • Oxidative stress is a central player in the pathogenesis of neurodegenerative conditions.
  • ROS accumulation directly correlates with synaptic loss and neuronal cell death.

Outlook:

  • Further research into antioxidant therapies could mitigate neurodegenerative processes.
  • Developing interventions that restore redox balance may offer new treatment avenues.

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