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Prediction of Antioxidant Capacity of Thiolate-Disulfide Systems Using Species-Specific Basicity Values
Tamás Pálla1,2, Béla Noszál1,2, Arash Mirzahosseini1,2
1Department of Pharmaceutical Chemistry, Semmelweis University, 1092 Budapest, Hungary.
Abstract:
The principal reactions that maintain redox homeostasis in living systems are the deprotonation of thiols, followed by the oxidative conversion of the produced thiolates into disulfides, which thus reduce the harmful oxidizing agents. The various biological thiols have different molecule-specific propensities to carry on the co-dependent deprotonation and redox processes. This study utilizes the known correlation between thiolate basicities and oxidizabilities, to quantify antioxidant or reducing capacities and pH-dependences of thiol-disulfide antioxidant systems, as a tool to find adequate molecules against oxidative stress.
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