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Minerals

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.

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Updated: Jun 11, 2025

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

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Impaired Upper Airway Muscle Function with Excessive or Deficient Dietary Intake of Selenium in Rats.

David P Burns¹, Sarah E Drummond¹, Stefanie Wölfel¹

¹Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, T12 XF62 Cork, Ireland.

Antioxidants (Basel, Switzerland)

|September 28, 2024

Summary

Selenium levels impact upper airway muscle function. Both deficient and excessive selenium impaired sternohyoid muscle function in rats, affecting selenoprotein levels and potentially contributing to obstructive sleep apnoea therapies.

Keywords:

chronic intermittent hypoxia (CIH)dietary selenium obstructive sleep apnoea (OSA)selenoprotein N (SELENON)selenoprotein S (SELENOS)selenoprotein W (SELENOW)

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Published on: December 5, 2017

Area of Science:

Muscle physiology and biochemistry
Nutritional science
Sleep medicine

Background:

Obstructive sleep apnoea (OSA) is linked to upper airway muscle dysfunction and various health issues.
Selenium is vital for muscle function, with both deficiency and excess potentially causing myopathy.
Selenoproteins play crucial roles in cellular processes, including muscle health.

Purpose of the Study:

To investigate the impact of dietary selenium levels on sternohyoid muscle function in rats.
To determine how selenium affects specific selenoproteins (SELENON, SELENOS, SELENOW) in the sternohyoid muscle.
To compare the effects of dietary selenium with chronic intermittent hypoxia, a model for OSA.

Main Methods:

Rats were fed diets with deficient, normal, or excessive selenium for two weeks.
Sternohyoid muscle contractile function was assessed ex vivo.
Serum selenium, glutathione antioxidant system activity, and key selenoprotein abundance were measured.

Main Results:

Both selenium deficiency and excess significantly impaired sternohyoid muscle contractile function.
Dietary selenium levels altered serum selenium concentrations and selenoprotein abundance (SELENOW increased with excess selenium).
Chronic intermittent hypoxia differentially affected selenoprotein levels (SELENON increased, SELENOW decreased).

Conclusions:

Dietary selenium levels critically influence upper airway muscle function.
Specific selenoproteins (SELENON, SELENOS, SELENOW) show distinct responses to dietary selenium and hypoxia.
Understanding these selenium-selenoprotein-muscle interactions may lead to new obstructive sleep apnoea treatments.