Related Experiment Video
Updated: Jun 11, 2025
07:42
Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes
Published on: January 10, 2022
4.1K
Serum N-Glycan Changes in Rats Chronically Exposed to Glyphosate-Based Herbicides
Moyinoluwa Adeniyi1, Cristian D Gutierrez Reyes1, Jesús Chávez-Reyes2
1Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA.
Biomolecules
|September 28, 2024
Summary
Chronic exposure to glyphosate-based herbicides (GBH) alters serum N-glycan profiles, particularly in male rats. These glycomic changes may indicate glyphosate toxicity and potential neurological effects.
Area of Science:
- Biochemistry
- Toxicology
- Glycomics
Background:
- Glyphosate is a widely used herbicide with debated safety profiles.
- Recent concerns highlight potential health effects, necessitating further investigation.
- N-glycosylation is a crucial protein modification linked to various health disorders, including neurological conditions.
Purpose of the Study:
- To identify glycomic alterations associated with glyphosate-induced toxicity.
- To investigate the impact of chronic glyphosate-based herbicide (GBH) exposure on serum N-glycans.
- To explore gender-specific responses to GBH exposure in N-glycan profiles.
Main Methods:
- Serum samples from rats chronically exposed to GBH were analyzed.
- N-glycomics profiling was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
- Significant N-glycan changes were validated using parallel reaction monitoring (PRM).
Main Results:
- Chronic GBH exposure induced significant changes in serum N-glycan composition.
- Sialylated and sialofucosylated N-glycans showed notable alterations.
- Male rats exhibited greater susceptibility to GBH-induced N-glycan changes compared to females.
Conclusions:
- Chronic GBH exposure impacts serum N-glycan profiles, suggesting a potential mechanism for glyphosate toxicity.
- Observed glycomic changes may serve as biomarkers for glyphosate-induced health effects, including neurological implications.
- Gender-specific responses highlight the need for tailored risk assessments in GBH exposure studies.
