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Oligosaccharide Assembly

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

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Automated Modular High Throughput Exopolysaccharide Screening Platform Coupled with Highly Sensitive Carbohydrate Fingerprint Analysis

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Advances in Microbial Exopolysaccharides: Present and Future Applications.

Huu-Thanh Nguyen^1,2, Thuy-Trang Pham^1,2, Phu-Tho Nguyen^1,2

¹Department of Biotechnology, An Giang University, Vietnam National University, 18 Ung Van Khiem, Long Xuyen City 880000, Vietnam.

|September 28, 2024

Summary

Microbial exopolysaccharides (EPSs) offer diverse applications and health benefits. This review details their composition, production, biological activities, and potential in medicine and industry.

Keywords:

exopolysaccharides immunobiotics lactic acid bacteria pharmaceutical applications probiotics

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Area of Science:

Microbiology
Biochemistry
Food Science

Background:

Microbial exopolysaccharides (EPSs) are gaining attention for their structural diversity and wide-ranging applications.
Their health-promoting benefits, biological activities, and physiological functions are of particular interest.

Purpose of the Study:

To provide a comprehensive review of microbial exopolysaccharides (EPSs).
To cover their chemical diversity, biosynthesis, sources, production, characterization, biological activities, and industrial applications.

Main Methods:

Literature review of scientific publications on microbial exopolysaccharides.
Synthesis of information regarding chemical composition, biosynthesis pathways, and bacterial sources (e.g., lactic acid bacteria, probiotics).
Analysis of technological aspects, production modes, characterization techniques, and documented biological functions.

Main Results:

Microbial EPSs exhibit significant chemical and structural diversity.
Key bacterial sources include lactic acid bacteria (LAB) and probiotics.
EPSs demonstrate various biological activities, including prebiotic, anticancer, and immunobiotic properties.

Conclusions:

Microbial EPSs possess substantial potential for applications in the food, medical, pharmaceutical, and agricultural industries.
Further research into their prebiotic, anticancer, and immunobiotic properties can unlock novel therapeutic and industrial uses.
Understanding their production and characterization is crucial for optimizing their application in various sectors.