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Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes

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Phenotypic Variation in Staphylococcus aureus during Colonisation Involves Antibiotic-Tolerant Cell Types.

Chloe M Burford-Gorst^1,2, Stephen P Kidd^1,2

¹Department of Molecular and Biomedical Sciences, School of Biological Sciences, The University of Adelaide, Adelaide, SA 5005, Australia.

Antibiotics (Basel, Switzerland)

|September 28, 2024

Summary

Staphylococcus aureus exhibits diverse cell types, enabling chronic infections by resisting treatments. Understanding these cell dynamics is key to developing new therapies for persistent Staphylococcus aureus diseases.

Keywords:

Staphylococcus aureus antibiotic tolerance coagulase-negative Staphylococcal species small colony variants

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Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

Area of Science:

Microbiology
Infectious Diseases
Bacterial Pathogenesis

Background:

Staphylococcus aureus is a common colonizer of humans.
It can cause various diseases, often becoming chronic and resistant to treatment.
Cellular heterogeneity within S. aureus populations contributes to its persistence.

Purpose of the Study:

To investigate the role of diverse S. aureus cell types in disease persistence.
To understand the drivers behind the selection or formation of these cell types.
To explore the presence of these cell types during both pathogenic and non-pathogenic colonization.

Main Methods:

Comparative analysis of S. aureus cell populations.
Investigation of host-pathogen interactions.
Study of co-colonization dynamics with coagulase-negative Staphylococci (CoNS).

Main Results:

S. aureus adopts multiple cell types within a single population.
These dynamics are influenced by host cell interactions and co-colonizing bacteria.
Cellular heterogeneity is observed during both colonization and infection.

Conclusions:

Understanding S. aureus cell type diversity is crucial for combating chronic infections.
Targeting specific cell types could lead to novel diagnostic and therapeutic strategies.
Further research into the drivers and implications of S. aureus cellular heterogeneity is warranted.