Immunological Tumor Microenvironment of Solitary Fibrous Tumors-Associating Immune Infiltrate with Variables of Prognostic Significance
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View abstract on PubMed
Summary
This summary is machine-generated.Solitary fibrous tumors (SFTs) have a variable prognosis. Immune microenvironment markers in SFTs showed prognostic significance but did not correlate with established risk stratification systems.
Area Of Science
- Oncology
- Immunology
- Pathology
Background
- Solitary fibrous tumors (SFTs) are rare neoplasms with heterogeneous clinical behavior.
- While most SFTs have favorable outcomes, some exhibit aggressive progression, recurrence, and metastasis.
- The prognostic role of the tumor microenvironment in SFTs remains incompletely understood.
Purpose Of The Study
- To investigate the prognostic value of the immunological tumor microenvironment (ITME) in SFTs.
- To assess the correlation between ITME components and established risk stratification systems (RSSs).
Main Methods
- Retrospective analysis of 52 fusion-confirmed SFTs with clinical follow-up.
- Immunohistochemical evaluation of immune cell markers (CD163, CD68, CD3, CD8, CD20, PD-L1, PD-1, LAG-1) and Ki67.
- Correlation of ITME markers with clinical outcomes, morphology, and RSSs.
Main Results
- Only one of 52 SFTs showed progression, which had high immune infiltrate (CD68, CD163, CD8, CD20).
- Immune cell presence did not correlate with assessed RSSs (Demicco, Sugita, G-score, Huang).
- Round-oval cell morphology associated with CD163+ macrophages; CD20+ lymphocytes correlated with less necrosis; PD-L1 expression linked to higher Ki67.
Conclusions
- SFT immunological tumor microenvironment components correlate with independent prognostic variables.
- The ITME did not demonstrate correlation with current risk stratification systems for SFTs.
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