Related Experiment Video
Updated: Jun 12, 2026
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
Increased Risk for Clinically Significant Sleep Disturbances in Mild Traumatic Brain Injury: An Approach to
Maya E O'Neil1,2,3, Danielle Krushnic1,2, William C Walker4,5
1HSR Center to Improve Veteran Involvement in Care (CIVIC), Portland VA Health Care System, Portland, OR 97239, USA.
Study Objectives:
The Federal Interagency Traumatic Brain Injury Research (FITBIR) Informatics System contains individual-patient-level traumatic brain injury (TBI) data, which when combined, allows for the examination of rates and outcomes for key subpopulations at risk for developing sleep disturbance.
Methods:
This proof-of-concept study creates a model system for harmonizing data (i.e., combining and standardizing data) across FITBIR studies for participants with and without a history of TBI to estimate rates of sleep disturbance and identify risk factors.
Results:
Three studies were eligible for harmonization (N = 1753). Sleep disturbance was common among those with a history of mild TBI (63%). Individuals with mild TBI were two to four times more likely to have sleep disturbance compared to those with no history of TBI.
Conclusions:
This study established methods, harmonization code, and meta-databases that are publicly available on the FITBIR website. We demonstrated how the harmonization of FITBIR studies can answer TBI research questions, showing that associations between TBI and sleep disturbance may be influenced by demographic factors.
