Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

403
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
403
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

448
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
448
Glaucoma: Overview01:25

Glaucoma: Overview

527
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
527
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

702
Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren...
702

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between silymarin and age-related macular degeneration in patients with liver dysfunction: a nationwide cohort study.

Scientific reports·2026
Same author

Validation of the postnatal growth and retinopathy of prematurity criteria in Taiwanese: A prospective cohort study.

Pediatrics and neonatology·2026
Same author

The role of TRPV1 in corneal wound healing under a thyroxine-induced TAO-like condition.

Experimental eye research·2026
Same author

Intraocular Pressure Changes Following Intraluminal Stent Removal From the Paul Glaucoma Implant: A Systematic Review and Meta-Analysis.

American journal of ophthalmology·2026
Same author

Single-mode nonlinear amplification of femtosecond pulses in a multimode-fiber regenerative amplifier.

Optics letters·2026
Same author

Peripheral Blood Mononuclear Cell Oxygen Consumption and Systemic Bioenergetics in Glaucoma Management.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Jun 11, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K

Glaucoma: Current and New Therapeutic Approaches.

Hsin-Pei Lee1, Ta-Hsin Tsung1, Yu-Chien Tsai1,2

  • 1Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Biomedicines
|September 28, 2024
PubMed
Summary

Glaucoma treatment is exploring neuroprotective drugs to save retinal ganglion cells when lowering eye pressure isn't enough. This study reviews current drug-based neuroprotection methods for future glaucoma therapy.

Keywords:
excitotoxicityglaucoma therapeutic approachesneurodegenerationneuroinflammationneuroprotectionoxidative stress

More Related Videos

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.0K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.3K

Related Experiment Videos

Last Updated: Jun 11, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.4K
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.0K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.3K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Glaucoma is characterized by retinal ganglion cell (RGC) loss.
  • Intraocular pressure (IOP) control is the standard glaucoma management.
  • Limitations of IOP-lowering treatments necessitate alternative strategies.

Purpose of the Study:

  • To analyze current drug-based neuroprotective therapies for glaucoma.
  • To evaluate the potential of neuroprotection in preventing RGC death.
  • To inform prospective glaucoma treatment guidelines.

Main Methods:

  • Literature review of drug-based neuroprotective agents.
  • Analysis of studies demonstrating RGC survival with neuroprotection.
  • Evaluation of the efficacy of current neuroprotective drug candidates.

Main Results:

  • Neuroprotective drugs show potential in reducing RGC mortality.
  • Several drug-based approaches are under investigation for glaucoma.
  • Evidence suggests neuroprotection can complement IOP control.

Conclusions:

  • Drug-based neuroprotection offers a promising avenue for glaucoma management.
  • Further research is needed to establish optimal neuroprotective treatments.
  • Neuroprotection may play a crucial role in preserving vision for glaucoma patients.