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Updated: Jun 11, 2025

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

Hematologic Inflammation Indices for Differentiating between Brucella, Pyogenic, and Tuberculous Spondylodiscitis.

Ali Irfan Baran¹, Irfan Binici¹, Yusuf Arslan²

¹Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Van Yuzuncu Yıl University, Van 65080, Turkey.

|September 28, 2024

Summary

Hematological inflammation indices (HIIs) can help differentiate infectious spondylodiscitis pathogens. Brucella infections showed significantly lower HII scores compared to pyogenic and tuberculous types, aiding diagnosis.

Keywords:

brucellosis infection inflammation neutrophil-to-lymphocyte ratio pyogenic spondylodiscitis tuberculous

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Area of Science:

Infectious Diseases
Hematology
Inflammation Markers

Background:

Infectious spondylodiscitis presents diagnostic and therapeutic challenges.
Hematological inflammation indices (HIIs) are blood-derived markers used in disease assessment.
Effective differentiation of causative pathogens is crucial for timely management.

Purpose of the Study:

To evaluate the utility of HIIs in distinguishing between different pathogens causing infectious spondylodiscitis.
To compare HII scores across Brucella, pyogenic, and tuberculous spondylodiscitis.
To identify potential diagnostic biomarkers for infectious spondylodiscitis etiology.

Main Methods:

Retrospective comparative study of 116 patients with infectious spondylodiscitis.
Categorization into Brucella (n=51), pyogenic (n=43), and tuberculous (n=22) groups based on causative pathogens.
Derivation and statistical comparison of HIIs (e.g., neutrophil/lymphocyte ratio) from complete blood counts.

Main Results:

Brucella spondylodiscitis group exhibited significantly lower HII scores compared to the pyogenic group (p < 0.05).
Brucella spondylodiscitis group also showed significantly lower HII scores than the tuberculous group (p < 0.05).
No significant difference in HII scores was observed between pyogenic and tuberculous spondylodiscitis groups (p > 0.05).

Conclusions:

HIIs demonstrate potential in differentiating Brucella spondylodiscitis from pyogenic and tuberculous forms.
These indices may serve as accessible tools for etiological discrimination in infectious spondylodiscitis.
Further research could validate HIIs for routine clinical application in diagnosing spondylodiscitis pathogens.