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Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction

Andreas Mitsis1, Elina Khattab1, Michael Myrianthefs1

  • 1Cardiology Department, Nicosia General Hospital, State Health Services Organization, Nicosia 2029, Cyprus.

Biomedicines
|September 28, 2024
PubMed

Insights

Chemerin, an adipokine, is a key player in acute myocardial infarction (AMI) pathophysiology. Targeting chemerin pathways may offer new therapeutic strategies for improving outcomes in AMI patients.

Area of Science:

  • Biochemistry
  • Cardiology
  • Immunology

Background:

  • Chemerin, an adipokine, is implicated in adipogenesis and inflammation.
  • Emerging evidence links chemerin to cardiovascular diseases, particularly acute myocardial infarction (AMI).
  • Chemerin influences inflammatory responses, endothelial function, and vascular remodeling in coronary artery disease (CAD).

Purpose of the Study:

  • To comprehensively review chemerin's role in AMI.
  • To detail chemerin's molecular mechanisms, clinical significance, and biomarker potential in AMI.
  • To explore therapeutic strategies targeting chemerin pathways for AMI treatment.

Main Methods:

  • Literature review of current research on chemerin in AMI.
  • Synthesis of findings on chemerin's molecular mechanisms and clinical implications.
  • Analysis of chemerin's potential as a diagnostic and prognostic biomarker.

Main Results:

  • Elevated chemerin levels correlate with adverse cardiovascular outcomes post-AMI.
  • Chemerin is associated with increased myocardial injury, left ventricular dysfunction, and inflammation.
  • Chemerin plays a multifaceted role in the pathophysiology of AMI.

Conclusions:

  • Chemerin is a significant biomarker in AMI, reflecting disease severity and prognosis.
  • Targeting chemerin pathways presents a promising therapeutic avenue for managing AMI.
  • Further research is warranted to fully elucidate chemerin's therapeutic potential in cardiovascular medicine.

Keywords:
acute myocardial infarctionadipokinesatherosclerosisbiomarkerscardiovascular diseasecardiovascular risk factorschemerincoronary artery diseaseinflammationpro-inflammatory cytokines

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