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  11. Covid-19 Inflammatory Syndrome: Lessons From Tnfri And Crp About The Risk Of Death In Severe Disease.

COVID-19 Inflammatory Syndrome: Lessons from TNFRI and CRP about the Risk of Death in Severe Disease.

Thaís Soares Farnesi-de-Assunção1, Ana Carolina de Morais Oliveira-Scussel1, Wellington Francisco Rodrigues1

  • 1Department of Microbiology, Immunology and Parasitology, Federal University of Triângulo Mineiro, Uberaba 38025-180, MG, Brazil.

Biomedicines
|September 28, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Elevated levels of soluble tumor necrosis factor receptors (sTNFRs) in severe COVID-19 patients predict mortality. The sTNFR1/sTNFR2 ratio combined with C-reactive protein (CRP) offers a powerful tool for clinical outcome prediction.

Area of Science:

  • Immunology
  • Virology
  • Critical Care Medicine
Keywords:
C-reactive proteinCOVID-19SARS-CoV-2TNF receptors

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Background:

  • Cytokine storm in severe COVID-19 causes significant tissue damage and mortality.
  • Tumor Necrosis Factor (TNF) superfamily mediators are implicated in severe COVID-19 pathogenesis.
  • Understanding the role of TNF receptors is crucial for predicting clinical outcomes.

Purpose of the Study:

  • To evaluate the correlation between soluble mediators of the TNF superfamily and clinical outcomes in severe COVID-19 patients.
  • To assess the predictive value of TNF receptors for clinical outcomes.
  • To identify biomarkers for managing hospitalized COVID-19 patients.

Main Methods:

  • Quantified serum levels of TNF superfamily soluble mediators in severe COVID-19 patients.
  • Categorized patients based on clinical outcomes (death vs. survival).
  • Employed statistical modeling, including logistic regression, to predict outcomes using hematological parameters, inflammatory markers, and TNF receptors.

Main Results:

  • Severe COVID-19 patients exhibited elevated serum TNF superfamily levels.
  • Soluble TNF receptor 1 (sTNFR1) levels were significantly higher in deceased patients.
  • The sTNFR1/sTNFR2 ratio and C-reactive protein (CRP) demonstrated high predictive accuracy for mortality, with an eight-fold increased odds ratio for unfavorable outcomes.

Conclusions:

  • The joint assessment of the sTNFR1/sTNFR2 ratio and CRP is a promising biomarker for predicting clinical outcomes in hospitalized COVID-19 patients.
  • These markers can aid in the clinical management and risk stratification of severe COVID-19 cases.
  • Further research into TNF superfamily mediators may reveal novel therapeutic targets.
TNF superfamily
clinical outcomes predictor
inflammatory mediators