Related Experiment Video

Updated: Jun 11, 2025

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
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Published on: August 1, 2018

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Porto-Sinusoidal Vascular Disease: A New Nomenclature Different from Idiopathic Non-Cirrhotic Portal Hypertension

Jie Liu1, Qian Zhang2, Yao Liu2

  • 1Department of Hepatology, Tianjin Second People's Hospital, Tianjin 300192, China.

Diagnostics (Basel, Switzerland)
|September 28, 2024
PubMed

Insights

Porto-sinusoidal vascular disease (PSVD) criteria aid early diagnosis. While PSVD patients may show higher liver stiffness, idiopathic non-cirrhotic portal hypertension (INCPH) patients face worse liver-related complications and survival outcomes.

Area of Science:

  • Hepatology
  • Vascular Biology
  • Diagnostic Criteria Development

Background:

  • Porto-sinusoidal vascular disease (PSVD) is a novel concept evolving from idiopathic non-cirrhotic portal hypertension (INCPH).
  • Comparing diagnostic criteria for PSVD and INCPH is crucial for understanding disease characteristics and prognosis.

Purpose of the Study:

  • To compare clinical, biochemical, histological features, and prognosis between PSVD and INCPH diagnostic criteria.
  • To evaluate the utility of novel PSVD criteria in patient diagnosis and management.

Main Methods:

  • Retrospective analysis of 65 patients with liver biopsies.
  • Review of clinical, pathological, and prognosis data based on PSVD and INCPH criteria.

Main Results:

  • 31 out of 65 PSVD patients also met INCPH criteria.
  • PSVD patients exhibited higher liver stiffness (LSM) than INCPH patients (p=0.039).
  • INCPH patients showed a significantly higher cumulative incidence of liver-related complications (86.95%) compared to PSVD patients (35.71%, p<0.001).

Conclusions:

  • Novel PSVD criteria enable earlier diagnosis.
  • Elevated LSM in PSVD patients may indicate co-existing liver diseases.
  • Prognosis and survival in PSVD are linked to portal hypertension severity.
Abstract

Keywords:
idiopathic non-cirrhotic portal hypertensionpathologicalportal hypertensionporto-sinusoidal vascular disease

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