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Updated: Jun 11, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Health Impacts of Pre-eclampsia: A Comprehensive Analysis of Maternal and Neonatal Outcomes

Flavius George Socol1, Elena Bernad2,3,4, Marius Craina2,3,4

  • 1Doctoral School, "Victor Babeş" University of Medicine and Pharmacy, Eftimie Murgu Sq. No.2, 300041 Timisoara, Romania.

Medicina (Kaunas, Lithuania)
|September 28, 2024
PubMed

Insights

Pre-eclampsia significantly impacts maternal and child health, leading to short-term complications and long-term chronic conditions for mothers. Children born to mothers with pre-eclampsia face increased risks of developmental and health issues.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Public Health

Background:

  • Hypertensive disorders in pregnancy, especially pre-eclampsia, present substantial risks to maternal and neonatal well-being.
  • Understanding the multifaceted health implications of pre-eclampsia is crucial for improving patient outcomes.

Purpose of the Study:

  • To analyze the short- and long-term health consequences for mothers and their children following pre-eclampsia.
  • To identify risk factors, diagnostic markers, and comparative outcomes between pre-eclamptic and non-pre-eclamptic pregnancies.

Main Methods:

  • Retrospective observational study of 235 patients (98 with pre-eclampsia, 137 without) from 2015-2018.
  • Data collection included maternal demographics, medical history, biochemical markers (proteinuria, sFlt-1, PlGF), and short/long-term health outcomes for mothers and children.

Main Results:

  • Pre-eclamptic mothers were older, had higher BMIs, and more comorbidities; they experienced higher rates of eclampsia, HELLP syndrome, and acute kidney injury.
  • Neonatal outcomes in the pre-eclampsia group included increased preterm birth, low birth weight, and NICU admissions.
  • Long-term, mothers with pre-eclampsia showed higher incidences of chronic hypertension, cardiovascular disease, diabetes, and mental health disorders; their children had elevated risks of developmental delays and chronic health issues.

Conclusions:

  • Pre-eclampsia has profound short- and long-term health effects on both mothers and children.
  • Early detection, timely intervention, and personalized management strategies are essential for mitigating risks and improving outcomes.

Keywords:
PlGFbiochemical markerslong-term health effectslow birth weightmaternal healthneonatal outcomespre-eclampsiapremature birthproteinuriasFlt-1

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