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Evaluation of Glucose 6-Phosphate Dehydrogenase, Pyruvate Kinase, and New Generation Inflammation Biomarkers in
Omer Okuyan1, Seyma Dumur2, Neval Elgormus3
1Department of Pediatrics, Medicine Hospital, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, Turkey.
Insights
Systemic immune inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) can aid in diagnosing prolonged jaundice in glucose 6-phosphate dehydrogenase (G6PD) deficiency. These markers may help streamline diagnosis and treatment, especially in emergency situations.
Area of Science:
- Neonatal Medicine
- Hematology
- Clinical Diagnostics
Background:
- Prolonged jaundice in neonates requires accurate diagnostic tools.
- Glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiencies are potential causes.
- Inflammatory markers like SII and NLR are being investigated for diagnostic utility.
Purpose of the Study:
- To evaluate clinical findings of G6PD and PK deficiency in prolonged neonatal jaundice.
- To determine the diagnostic value of SII, NLR, and PLR in neonatal prolonged jaundice.
Main Methods:
- Retrospective analysis of 167 full-term neonates with hyperbilirubinemia and jaundice persisting beyond 10 days.
- Inclusion criteria: serum bilirubin > 10 mg/dL.
- Assessment of G6PD and PK activity, alongside SII, NLR, and PLR levels.
Main Results:
- G6PD activity showed negative correlations with NLR, SII, age, and hematocrit.
- A moderate negative correlation was found between G6PD activity and SII after adjustment.
- PK activity did not show significant correlations with other measured parameters.
Conclusions:
- NLR and SII are easily calculable and advantageous in evaluating prolonged jaundice associated with G6PD deficiency.
- These indices may reduce the need for further tests and aid in treatment regulation.
- NLR and SII can assist in early diagnosis and decision-making during emergencies.
Abstract:
Background and Objectives: To evaluate the clinical findings of glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency in prolonged jaundice and to determine whether the systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) can be used in the diagnosis of neonatal prolonged jaundice. Materials and Methods: Among full-term neonates with hyperbilirubinemia who were admitted to Medicine Hospital between January 2019 and January 2024 with the complaint of jaundice, 167 infants with a serum bilirubin level above 10 mg/dL, whose jaundice persisted after the 10th day, were included in this study. Results: G6PD activity was negatively correlated with NLR, SII, age, and hematocrit (Hct). There was a weak negative correlation between G6PD and NLR and a moderate negative correlation between G6PD activity and SII when adjusted for age and Hct. PK activity showed no significant correlation with G6PD, NLR, PLR, SII, age, and Hct. A linear relationship was observed between G6PD activity and SII and NLR. Conclusions: NLR and SII can be easily calculated in the evaluation of prolonged jaundice in G6PD deficiency has a considerable advantage. NLR and SII levels may contribute by preventing further tests for prolonged jaundice and regulating its treatment. It may be useful to form an opinion in emergencies and in early diagnostic period.
