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NR0B2 Is a Key Factor for Gastric Diseases: A GEO Database Analysis Combined with Drug-Target Mendelian
Zhengwen Li1, Lijia Xu1, Dongliang Huang1
1School of Pharmacy, Chengdu University, 2025 Chengluo Avenue, Chengdu 610106, China.
Genes
|September 28, 2024
Summary
Small Heterodimer Partner (SHP; NR0B2) expression is linked to gastric diseases, with lower levels in gastric cancer and higher levels in gastritis. This study confirms SHP
Area of Science:
- Genomics and Bioinformatics
- Molecular Biology
- Oncology
Background:
- Small Heterodimer Partner (SHP; NR0B2) is an orphan nuclear receptor regulating metabolic processes and a potential cancer therapeutic target.
- Investigating NR0B2's role in gastric diseases may reveal new treatment and drug development avenues.
Purpose of the Study:
- To explore the correlation between NR0B2 gene expression and the risk of gastric diseases.
- To identify potential therapeutic targets within NR0B2 pathways for gastric disease treatment.
Main Methods:
- Utilized the Gene Expression Omnibus (GEO) database for NR0B2 expression profiles in gastric diseases.
- Employed Weighted Correlation Network Analysis (WGCNA) for co-expressed genes and Gene Ontology (GO) enrichment analysis for pathway identification.
- Applied Xcell method for immune infiltration analysis and Mendelian Randomization (MR) to assess causal relationships.
Main Results:
- NR0B2 expression was reduced in gastric cancer and increased in gastritis.
- GO and Gene Set Enrichment Analysis (GSEA) indicated NR0B2's involvement in oxidation-related processes.
- Low NR0B2 expression correlated with poor gastric cancer prognosis and a causal relationship was established between NR0B2 expression and gastric disease risk.
Conclusions:
- Confirmed a causal link between NR0B2 expression and the risk of gastric diseases, including gastric cancer, ulcer, and gastritis.
- Highlighted NR0B2's role in gastric cancer progression and its association with Treg immune cells.
- Suggests NR0B2 as a potential therapeutic target for modulating gastric disease progression.
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