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Published on: December 11, 2017
Long-Term Results and Quality of Life after Surgery for Acute Aortic Dissection Type A: Contemporary Single-Centre
Nora Goebel1, Simone A Holder1, Franziska Huether1
1Department of Cardiovascular Surgery, Robert Bosch Hospital, 70376 Stuttgart, Germany.
Insights
Emergency surgery for acute aortic dissection type A shows improved 30-day and 10-year survival rates over time, despite increased patient complexity. Quality of life remains significantly impaired post-surgery.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Aortic Disease Management
Background:
- Acute aortic dissection type A carries high morbidity and mortality.
- Emergency surgical intervention is critical for survival.
- Long-term outcomes and quality of life post-surgery require ongoing evaluation.
Purpose of the Study:
- To assess long-term outcomes and quality of life after emergency surgery for acute aortic dissection type A.
- To compare early versus late surgical periods regarding mortality and reoperation rates.
- To analyze risk factors influencing outcomes in aortic dissection surgery.
Main Methods:
- Retrospective analysis of 413 patients undergoing surgery for acute aortic dissection type A between 2000 and 2016.
- Comparison of outcomes between two periods: 2000-2007 (early) and 2008-2016 (late).
- Assessment of 30-day mortality, follow-up mortality, reoperation rates, and quality of life using the SF-36 survey.
Main Results:
- Perioperative risk (Euroscore) significantly increased from 24.9% to 38.0% (p < 0.001).
- Thirty-day mortality significantly decreased from 26.7% to 17.4% (p = 0.03).
- Ten-year survival improved from 53.4% to 69.7% (p = 0.04), with comparable reoperation rates (74.0% vs. 85.7%, p = 0.28).
Conclusions:
- Surgical outcomes for type A aortic dissection have significantly improved over time, evidenced by reduced 30-day and enhanced 10-year survival.
- Despite improvements, quality of life remains significantly impaired compared to the general population.
- Increased surgical complexity and patient risk are associated with improved, rather than worsened, outcomes in recent years.
Abstract:
Background: Aortic dissection is still afflicted with significant morbidity and mortality. This research seeks to assess long-term outcomes and quality of life after emergency surgery for acute aortic dissection type A. Methods: A total of 413 patients were analysed, who had been operated upon between 2000 and 2016 at our centre. We compared our results of the early (2000-2007) versus late (2008-2016) period with regards to 30-day and follow-up mortality and need for reoperation, including risk factor analysis. Quality of life was assessed via the SF-36 survey. Results: Calculated perioperative risk by EuroSCORE increased significantly from early, 24.9%, to late, 38.0%, p < 0.001. Thirty-day rates of mortality decreased significantly from 26.7% to 17.4%, p = 0.03. Survival at 1-, 5-, and 10-years was 92.3% vs. 91.8% (p = 0.91), 75.2% vs. 81.0% (p = 0.29), and 53.4% vs. 69.7% (p = 0.04). Freedom from reoperation was comparable between groups at follow-up: 74.0% vs. 85.7%, p = 0.28. Quality of life was impaired. Conclusions: Despite more complex severity of disease and operative procedures, the results of surgery for type A aortic dissection improved significantly over time at 30-day and 10-year follow-up. Quality of life was significantly impaired compared to a healthy reference population.
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