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Updated: Jun 11, 2025

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
07:02

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

Published on: December 16, 2021

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Pathophysiology of Arginases in Cancer and Efforts in Their Pharmacological Inhibition

Patrycja Marzęta-Assas1, Damian Jacenik1,2, Zbigniew Zasłona1

  • 1Molecure S.A., 101 Żwirki i Wigury St., 02-089 Warsaw, Poland.

International Journal of Molecular Sciences
|September 28, 2024
PubMed

Insights

Arginases (ARG1 and ARG2) are crucial enzymes implicated in cancer and inflammatory diseases. Inhibiting their activity offers a promising therapeutic strategy for various human conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathology

Background:

  • Arginases (ARG1 and ARG2) are enzymes that metabolize L-arginine, impacting cellular processes.
  • These enzymes play significant roles in cancer development, immune suppression, and metabolic pathways.
  • Arginase activity is also linked to cardiovascular diseases, stroke, and inflammation.

Purpose of the Study:

  • To provide a comprehensive overview of arginase functions and their roles in disease.
  • To summarize recent advances in targeting arginases for therapeutic interventions.
  • To explore potential future drug candidates for arginase inhibition.

Main Methods:

  • Review of experimental, preclinical, and clinical studies.
  • Analysis of biological and physiological functions of ARG1 and ARG2.
  • Examination of molecular mechanisms and affected metabolic pathways.

Main Results:

  • Arginases influence cancer cell proliferation, migration, apoptosis, and immunosuppression.
  • Competition between arginases and nitric oxide synthase (NOS) for L-arginine is critical.
  • Numerous studies highlight arginases' involvement in diverse pathological conditions.

Conclusions:

  • Targeting arginase activity presents a viable therapeutic avenue for numerous human diseases.
  • Understanding arginase pathways is key to developing novel treatments.
  • Ongoing clinical trials and drug development show promise for arginase-targeted therapies.
Keywords:
L-argininearginasecancerdrug therapyinhibitorsmetabolism

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