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Circulating Polyploid Giant Cancer Cells, a Potential Prognostic Marker in Patients with Carcinoma
Ludmilla Thomé Domingos Chinen1,2, Jacqueline Aparecida Torres3, Vinicius Fernando Calsavara4
1Hcor Research Institute, São Paulo 04004-030, Brazil.
International Journal of Molecular Sciences
|September 28, 2024
Summary
Circulating Polyploid Giant Cancer Cells (PGCCs) detected via liquid biopsy indicate poor cancer survival. This discovery highlights PGCCs as a potential prognostic marker for guiding cancer therapy.
Area of Science:
- Oncology
- Cancer Biology
- Clinical Diagnostics
Background:
- Polyploid Giant Cancer Cells (PGCCs) are known for therapy resistance.
- The clinical utility of detecting circulating PGCCs remains largely uninvestigated.
Purpose of the Study:
- To determine if circulating PGCCs can be detected in blood.
- To assess the prognostic value of circulating PGCCs in various carcinomas.
Main Methods:
- Retrospective study of 228 carcinoma patients (colon, gastric, NSCLC, breast, anal, kidney).
- Utilized ISET® liquid biopsy and cytopathology for PGCC detection.
- Mean follow-up of 44.74 months.
Main Results:
- PGCCs detected in 20.18% of patients (46/228).
- Detection rates were 14.47% in non-metastatic and 29.85% in metastatic cases.
- Circulating PGCC presence significantly correlated with poorer overall survival.
Conclusions:
- Circulating PGCCs are detectable using liquid biopsy.
- PGCCs show significant potential as a prognostic biomarker in cancer.
- Further research into anti-PGCC therapies and prognostic applications is warranted.
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