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Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 and/or

Vladimir Volloch1, Sophia Rits-Volloch2,3

  • 1Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA.

International Journal of Molecular Sciences
|September 28, 2024
PubMed

Keywords:
AβPP-independent generation of iAβRNA-dependent asymmetric amplification of human AβPP mRNAamyloid cascade hypothesis 2.0 (ACH2.0)conventional and unconventional Alzheimer’s diseasedepletion of iAβ via the activation of BACE1 and/or BACE2initiation of translation from the AUG codon encoding Met671 of the intact or 5′-truncated human AβPP mRNAintraneuronal Aβ (iAβ)neuronal integrated stress response (ISR)suppression of the neuronal ISRtherapeutic strategies for conventional and unconventional Alzheimer’s disease

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