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Related Experiment Video

Updated: Jun 11, 2025

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
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Anti TNF-Alpha Treatment Improves Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients.

Alexandru Caraba1, Oana Stancu2, Viorica Crișan3

  • 1Third Internal Medicine, Diabetes and Rheumatology Department, University of Medicine and Pharmacy "Victor Babeș", 300041 Timișoara, Romania.

International Journal of Molecular Sciences
|September 28, 2024
PubMed
Summary

Nailfold capillaroscopy reveals microvascular endothelial dysfunction in rheumatoid arthritis (RA) patients. Anti-TNF-alpha treatment significantly improves this dysfunction over 12 months.

Keywords:
anti TNF-alpha therapymicrovascular endothelial dysfunctionnailfold capillaroscopyrheumatoid arthritis

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Area of Science:

  • Rheumatology
  • Vascular Biology
  • Medical Imaging

Background:

  • Rheumatoid arthritis (RA) is linked to cardiovascular disease, with microvascular endothelial dysfunction being an early indicator.
  • Nailfold capillaroscopy offers a non-invasive method to assess microvascular structure and function.
  • Endothelial dysfunction is a critical initial step in atherosclerosis development.

Purpose of the Study:

  • To evaluate microvascular endothelial dysfunction in RA patients using nailfold capillaroscopy.
  • To assess the impact of 12 months of anti-TNF-alpha therapy on microvascular function in RA.
  • To correlate nailfold capillaroscopy findings with RA disease activity and inflammatory markers.

Main Methods:

  • 70 RA patients and 70 healthy controls underwent nailfold capillaroscopy to measure capillary density (Db, Dh, Dc).
  • RA patients had laboratory tests including rheumatoid factor, anti-CCP antibodies, TNF-α, CRP, ESR, and DAS28 for disease activity.
  • Follow-up capillaroscopy and laboratory assessments were performed after 12 months of anti-TNF-alpha treatment.

Main Results:

  • Baseline capillary density (Db, Dh, Dc) was significantly lower in RA patients compared to controls (p < 0.0001).
  • Reduced capillary density correlated with RA disease activity (DAS28) and elevated TNF-α levels (p < 0.05).
  • After 12 months of anti-TNF-alpha treatment, significant improvement in microvascular endothelial function was observed (p < 0.0001).

Conclusions:

  • Nailfold capillaroscopy is effective in assessing microvascular endothelial dysfunction in RA.
  • Anti-TNF-alpha therapy demonstrates a positive effect on improving microvascular function in RA patients.
  • Microvascular health in RA patients can be monitored and potentially improved with targeted therapies like anti-TNF-alpha agents.