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Updated: Jun 11, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Published on: June 15, 2016

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ETS Transcription Factors in Immune Cells and Immune-Related Diseases

Yaxu Yang1, Xue Han2, Lijun Sun1

  • 1Department of Physiology and Pathophysiology, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing 100191, China.

International Journal of Molecular Sciences
|September 28, 2024
PubMed

The development, differentiation, and function of immune cells are precisely regulated by transcription factors. The E26 transformation-specific (ETS) transcription factor family is involved in various physiological and pathological processes by regulating cell proliferation, differentiation, and apoptosis. Emerging evidence has suggested that ETS family proteins are intimately involved in the development and function of immune cells. This review summarizes the role of the ETS family in immune cells and immune-related disorders. Seven transcription factors within the ETS family, including PU.1, ETV5, ETV6, ETS1/2, ELK3, and ELF1, play essential roles in the development and function of T cells, B cells, macrophages, neutrophils, and dendritic cells. Furthermore, they are involved in the occurrence and development of immune-related diseases, including tumors, allergies, autoimmune diseases, and arteriosclerosis. This review is conducive to a comprehensive overview of the role of the ETS family in immune cells, and thus is informative for the development of novel therapeutic strategies targeting the ETS family for immune-related diseases.

Keywords:
ETS familyETV5PU.1immune cellimmune-related diseasestranscription factor

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