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Updated: Jun 11, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Challenging the Norm: The Unrecognized Impact of Soluble Guanylyl Cyclase Subunits in Cancer

María Teresa L Pino1, María Victoria Rocca1, Lucas H Acosta1

  • 1Centro de Altos Estudios en Ciencias Humanas y de la Salud, CONICET-Universidad Abierta Interamericana, Buenos Aires C1270AAH, Argentina.

International Journal of Molecular Sciences
|September 28, 2024
PubMed

Insights

This review highlights the crucial roles of soluble guanylyl cyclase (sGC) subunits beyond their enzymatic activity, particularly in cancer. Understanding these sGC roles offers new therapeutic avenues.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Nitric oxide (NO) signaling is vital in physiology and disease.
  • Soluble guanylyl cyclase (sGC), the primary NO receptor, comprises sGCα1 and sGCβ1 subunits.
  • The functions of sGC subunits beyond enzymatic activity have been historically overlooked.

Purpose of the Study:

  • To re-evaluate and emphasize the significance of sGCα1 and sGCβ1 subunits.
  • To compile and analyze overlooked information on sGC subunit functions.
  • To explore the roles of sGC subunits in various tumor models.

Main Methods:

  • Literature review and analysis of existing data.
  • Compilation of information on sGC expression regulation (transcriptional, protein interactions).
  • Emphasis on evidence of sGC subunit actions in cancer models.

Main Results:

  • sGC subunits have critical roles beyond NO-stimulated enzymatic activity.
  • sGC expression is regulated at transcriptional and post-translational levels.
  • Specific evidence demonstrates the actions of sGC subunits in different tumor types.

Conclusions:

  • sGC subunits are key players in tumor biology.
  • Investigating sGC subunit functions can reveal novel therapeutic targets in cancer.
  • This review provides a foundation for future research into sGC-targeted cancer therapies.
Keywords:
cancercell signalingnitric oxide pathwaysoluble guanylyl cyclase α1 and β1 subunits

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