Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18-Optimization, Characterization, and Cosmetic...

Area of Science:

• Cosmetic Science
• Nanotechnology
• Dermatology

Background:

• Solid lipid nanoparticles (SLNs) offer a promising delivery system for cosmetic actives.
• Retinol and oligopeptides are known for their potent anti-aging properties.
• Ensuring the stability of nanocarrier formulations is crucial for cosmetic applications.

Purpose of the Study:

• To optimize and ensure the stability of solid lipid nanoparticles (SLNs) incorporating retinol and pentapeptide-18.
• To evaluate the physicochemical properties of SLN dispersions under various storage conditions.
• To confirm the suitability of the developed SLN formulation as a cosmetic raw material for anti-aging products.

Main Methods:

• High shear homogenization (HSH) was employed for SLN production.
• SLN dispersions were formulated with non-incorporated SLNs, SLNs with retinol, and SLNs with retinol and pentapeptide-18.
• Physicochemical parameters including particle size (Z-Ave), polydispersity index (PDI), and zeta potential (ZP) were assessed after 4 weeks of storage at 4, 25, and 45 °C.

Main Results:

• Optimized SLN dispersions containing retinol and pentapeptide-18 exhibited stable physicochemical properties.
• Key parameters at 25 °C after 4 weeks: Z-Ave = 134.7 ± 0.3 nm, PDI = 0.269 ± 0.017, ZP = 42.7 ± 1.2 mV.
• The results validated the effectiveness of the HSH method and optimization process.

Conclusions:

• The optimized SLN formulation containing retinol and pentapeptide-18 demonstrates excellent stability and desirable physicochemical characteristics.
• The developed SLN dispersion is suitable for use as a raw material in cosmetic products targeting anti-aging effects.
• This research supports the advancement of nanotechnology in cosmetic formulations for enhanced efficacy.