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Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
CD68-Negative Histiocytoses with Cardiac Involvement, Associated with COVID-19
Lubov Mitrofanova1, Lubov Korneva1, Igor Makarov1
1Almazov National Medical Research Centre, 197341 St. Petersburg, Russia.
Insights
Rare cardiac histiocytoses, negative for CD68 but positive for SARS-CoV-2 spike protein in M2 macrophages, were observed in four patients. Further research is needed to explore a potential COVID-19 link.
Area of Science:
- Pathology
- Immunology
- Cardiology
Background:
- Histiocytoses are rare myeloid cell infiltrative diseases with variable clinical presentations.
- Cardiac involvement in histiocytosis is exceptionally uncommon.
Observation:
- Four cases of cardiac histiocytosis were identified: Erdheim-Chester disease, xanthogranulomatous myopericarditis, xanthogranulomatous constrictive pericarditis, and infantile xanthogranulomatosis.
- All cases presented with CD68-negative xanthogranuloma cells, a rare finding in cardiac histiocytosis.
Findings:
- Xanthogranuloma cells in all cases expressed CD163, indicating an M2 macrophage phenotype.
- A significant proportion of these M2 macrophages expressed the SARS-CoV-2 spike protein.
- CD68 expression was minimal, observed only in scattered cells.
Implications:
- These findings suggest an extremely rare form of cardiac histiocytosis potentially associated with SARS-CoV-2.
- The presence of viral antigen in M2 macrophages warrants further investigation into a possible indirect link between COVID-19 and histiocytosis development.
- This study highlights the need for expanded research to confirm and understand this potential association.
Abstract:
Histiocytoses are rare diseases characterised by infiltration of affected organs by myeloid cells with a monocyte or dendritic cell phenotype. Symptoms can range from self-resolving localised forms to multisystemic lesions requiring specific treatment. To demonstrate extremely rare cases of CD68-negative cardiac histiocytosis with expression of SARS-CoV-2 antigen in infiltrate cells. We demonstrated a case of Erdheim-Chester disease in a 67-year-old man with pericardial involvement and positive dynamics with vemurafenib treatment, an autopsy case of xanthogranulomatous myopericarditis in a 63-year-old man, surgical material of xanthogranulomatous constrictive pericarditis in a 57-year-old man, and an autopsy case of xanthogranulomatosis in a 1-month-old girl. In all cases, xanthogranuloma cells expressed CD163, many of them spike protein SARS-CoV-2, while CD68 expression was detected only in single cells. In this article, we demonstrated four cases of extremely rare CD68-negative cardiac xanthogranulomatosis in three adults and one child with expression of the spike protein SARS-CoV-2 in M2 macrophages. This potential indirect association between COVID-19 and the development of histiocytosis in these patients warrants further investigation. To substantiate this hypothesis, more extensive research is needed.
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