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The Hidden Relationship between Intestinal Microbiota and Immunological Modifications in Preeclampsia Pathogenesis
Enrica Zambella1, Beatrice Peruffo1, Alice Guarano2
1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy.
International Journal of Molecular Sciences
|September 28, 2024
Summary
Preeclampsia, a pregnancy complication, may be linked to gut microbiota changes. Research suggests a connection between intestinal dysbiosis and immune system alterations in preeclamptic women.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Microbiome Research
Background:
- Preeclampsia is a serious pregnancy disorder marked by high blood pressure and organ involvement.
- It significantly impacts maternal and neonatal health, potentially causing long-term maternal health issues.
- The gut microbiota influences the immune system and may play a role in preeclampsia development.
Purpose of the Study:
- To review the immune system's role in preeclampsia pathogenesis.
- To summarize current literature on the link between preeclampsia and intestinal microbiota alterations.
Main Methods:
- A narrative review of studies published in PubMed and Embase from January 1990 to March 2024.
- Focus on studies comparing microbial composition and immune effects in preeclamptic versus non-preeclamptic individuals.
Main Results:
- Preeclampsia is potentially associated with intestinal dysbiosis.
- Preeclamptic women exhibit elevated endotoxin, pro-inflammatory cytokines, and T helper 17 cells.
- Specific microbial and metabolite contributions to immune imbalance in preeclampsia require further investigation.
Conclusions:
- Alterations in the intestinal microbiota may contribute to the immune dysregulation observed in preeclampsia.
- Further research is needed to identify specific microbial factors and metabolites involved in preeclampsia pathogenesis.
Keywords:
gestational hypertensiongut metabolomegut microbiotahypertensive pregnancy disorderpreeclampsiaMore Related Videos
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