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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Graphene-Oxide Peptide-Containing Materials for Biomedical Applications.

Andreea Gostaviceanu1,2, Simona Gavrilaş1,3, Lucian Copolovici1,3

  • 1Institute for Interdisciplinary Research, Aurel Vlaicu University of Arad, Elena Drăgoi St., No. 2, 310330 Arad, Romania.

International Journal of Molecular Sciences
|September 28, 2024
PubMed
Summary

Graphene-based materials (GBMs) show promise in biomedicine, particularly graphene oxide (GO) functionalized with peptides and proteins. These advancements are crucial for developing new diagnostic tools, targeted therapies, and regenerative medicine strategies.

Keywords:
antibacterialapplicationsbiomedicinecancergraphenegraphene oxidepeptidesproteins

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Graphene-based materials (GBMs), especially graphene oxide (GO), are versatile nanomaterials with significant biomedical potential due to their unique properties and functional groups.
  • GO's application is currently limited by toxicity and environmental concerns, necessitating careful functionalization strategies.
  • Peptides and proteins can be attached to GO surfaces via non-covalent and covalent methods, enhancing its utility.

Purpose of the Study:

  • To review the biomedical applications of graphene oxide (GO) functionalized with peptides and proteins.
  • To explore the methods for GO functionalization and its impact on various biomedical fields.
  • To highlight the potential and challenges of using GBMs in healthcare.

Main Methods:

  • Review of literature on graphene oxide (GO) functionalization with peptides and proteins.
  • Analysis of non-covalent (π-π stacking, electrostatic, hydrophobic, hydrogen bonding, van der Waals) and covalent (amide formation, esterification, thiol chemistry, click chemistry) bonding strategies.
  • Examination of GO's role in biosensing, theranostic imaging, targeted cancer therapy, tissue engineering, and antimicrobial applications.

Main Results:

  • Functionalized GO demonstrates enhanced capabilities in sensitive biomarker detection for biosensing.
  • GO-based theranostic systems offer integrated diagnostics and therapy with real-time monitoring.
  • GO scaffolds promote bone, muscle, and nerve tissue regeneration and improve antimicrobial properties for medical devices.

Conclusions:

  • Graphene oxide functionalized with peptides and proteins offers significant potential across diverse biomedical applications, including diagnostics, therapeutics, and regenerative medicine.
  • Further research is required to address challenges in GO stability and scalability for widespread clinical adoption.
  • GBMs represent a promising frontier in advancing healthcare solutions, from targeted cancer treatments to improved medical devices.